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An integrated model for structure optimization and technology screening of urban wastewater systems

Yue HUANG,Xin DONG,Siyu ZENG,Jining CHEN

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 6,   Pages 1036-1048 doi: 10.1007/s11783-015-0792-z

Abstract: In this study, a multi-objective optimization model of an integrated urban wastewater system was developedThe model encompasses subsystems, such as a sewer system, stormwater management, municipal wastewaterThe developed model can be used to assist decision makers in the preliminary planning of system structure

Keywords： urban wastewater system     integrated modeling     multi-objective optimization     non-dominated sorting genetic algorithm (NSGA-II)    

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Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Frontiers of Medicine 2018, Volume 12, Issue 1,   Pages 116-121 doi: 10.1007/s11684-017-0600-1

Abstract: Screening for lung cancer coupled with earlier intervention has long been studied as an approach to mortalityOn the basis of this finding, LDCT has been recommended for lung cancer screening in high-risk populationsIn addition, intractable problems gradually emerged with the progress of LDCT screening.This paper summarizes and discusses the main observations and challenges of LDCT screening for lung cancerComplementary biomarkers and technical improvement are expected in the field of lung cancer screening

Keywords： lung cancer     low-dose computerized tomography     early detection     opportunities     challenges    

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Systematic screening procedure and innovative energy-saving design for ionic liquid-based extractive

Frontiers of Chemical Science and Engineering 2023, Volume 17, Issue 1,   Pages 34-45 doi: 10.1007/s11705-022-2234-3

Abstract: In this study, a systematic screening strategy and innovative energy-saving design for ionic liquid-based

Keywords： ionic liquid     entrainer screening     feasibility analysis     extractive distillation    

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Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

Frontiers of Environmental Science & Engineering 2023, Volume 17, Issue 9, doi: 10.1007/s11783-023-1716-y

Abstract:

● A systematic framework was developed to identify i-PPCPs for landfill leachate.

Keywords： Landfill leachates     PPCPs     Indicator     Screening criteria     Source-specificity    

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A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane Article

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Engineering 2023, Volume 25, Issue 6,   Pages 222-233 doi: 10.1016/j.eng.2022.02.014

Abstract: However, an efficient model for screening probiotic strains against specific metabolic diseases has notIn the present study, a Caco-2 cell monolayer membrane model treated with tumor necrosis factor (TNF-against osteoporosis and alcoholic liver disease, respectively, suggesting the reliability of the cell modelThis study established a potential in vitro approach based on a Caco-2 cell monolayer membrane modelfor the efficient screening of potential probiotics against specific metabolic diseases such as osteoporosis

Keywords： Lactobacillus     Intestinal barrier     Caco-2 cells     Screening model     Metabolic diseases    

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Combination of ARTP mutagenesis and color-mediated high-throughput screening to enhance 1-naphthol yield

Chenggang Qiu, Alei Zhang, Sha Tao, Kang Li, Kequan Chen, Pingkai Ouyang

Frontiers of Chemical Science and Engineering 2020, Volume 14, Issue 5,   Pages 793-801 doi: 10.1007/s11705-019-1876-2

Abstract: Then, a microbial clone screening system was used to accelerate the operation.Meanwhile, a novel color-mediated high-throughput screening using 4-aminoantipyrine was performed to

Keywords： Bacillus cereus QCG     naphthalene     1-naphthol     ARTP mutagenesis     high-throughput screening     4-aminoantipyrine    

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Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Frontiers of Medicine 2021, Volume 15, Issue 6,   Pages 903-912 doi: 10.1007/s11684-021-0871-4

Abstract: A nationwide survey was conducted from October 2018 to September 2019 to assess the prevalence of hyperhomocysteinemia (Hhcy) and its influencing factors in China. A standardized questionnaire was used to collect information. Hhcy was defined as the level of serum homocysteine (HCY) ≥15.0 µmol/L. The H-type hypertension (HHYP) was defined as hypertension with an elevated serum HCY (≥15.0 µmol/L). Finally, 110 551 residents ≥40 years of age from 31 provinces in the mainland of China were included. Overall, the median serum HCY level was 10.9 µmol/L (interquartile range 7.9–15.1). A total of 28 633 participants (25.9%) were defined as Hhcy. The Hhcy prevalence ranged from 7.9% in Shanghai to 56.8% in Tianjin. The data showed that serum HCY levels were associated with age, male gender, cigarette smoking, hypertension, diabetes, ethnicity, endurance in exercise (inverse), and fruit and vegetable intake (inverse). In addition, 15 486 participants were defined as HHYP, and the rate was 14.0%. HHYP was an independent predictor of stroke with an adjusted odds ratio of 1.752 (95% CI 1.338–2.105). The geographical distribution pattern of the Hhcy epidemic reflects dynamic differences, and national strategies should be carried out to further improve the care of patients with Hhcy across China.

Keywords： homocysteine     hyperhomocysteinemia     H-type hypertension     Chinese    

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Screening of potential aquatic probiotics from the major microflora of guppies (

Aparna BALAKRISHNA, T. R. KEERTHI

Frontiers of Chemical Science and Engineering 2012, Volume 6, Issue 2,   Pages 163-173 doi: 10.1007/s11705-012-1283-4

Abstract: were obtained from the skin, gills, guts and intestines of the guppy, (collected from a government model

Keywords： aquaculture     normal flora     immunomodulatory effect     probiotic     antagonistic principle     bacteriocin like inhibitory substances    

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Low-k integration: Gas screening for cryogenic etching and plasma damage mitigation

Romain Chanson, Remi Dussart, Thomas Tillocher, P. Lefaucheux, Christian Dussarrat, Jean François de Marneffe

Frontiers of Chemical Science and Engineering 2019, Volume 13, Issue 3,   Pages 511-516 doi: 10.1007/s11705-019-1820-5

Abstract: The integration of porous organo-silicate low- materials has met a lot of technical challenges. One of the main issues is plasma-induced damage, occurring for all plasma steps involved during interconnects processing. In the present paper, we focus on porous SiOCH low- damage mitigation using cryogenic temperature so as to enable micro-capillary condensation. The aim is to protect the porous low- from plasma-induced damage and keep the -value of the material unchanged, in order to limit the RC delay of interconnexion levels while shrinking the microchip dimension. The cryogenic temperature is used to condense a gas inside the porous low- material. Then, the etching process is performed at the temperature of condensation in order to keep the condensate trapped inside the material during the etching. In the first part of this work, the condensation properties of several gases are screened, leading to a down selection of five gases. Then, their stability into the porous structure is evaluated at different temperature. Four of them are used for plasma damage mitigation comparison. Damage mitigation is effective and shows negligible damage for one of the gases at –50°C.

Keywords： low-k     nanotechnology     micro-electronics     cryo-etching     plasma processing    

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High-Throughput Screening Using Fourier-Transform Infrared Imaging Article

Erdem Sasmaz, Kathleen Mingle, Jochen Lauterbach

Engineering 2015, Volume 1, Issue 2,   Pages 234-242 doi: 10.15302/J-ENG-2015040

Abstract:

Efficient parallel screening of combinatorial libraries is one of the most challenging aspects of, rapid-scanning Fourier-transform infrared (FTIR) imaging is one of the fastest and most versatile screening

Keywords： high-throughput     FTIR imaging     screening     cobalt oxide     CO oxidation    

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Pharmaceutical compounds in aquatic environment in China: locally screening and environmental risk assessment

Yongshan CHEN,Xiuping XI,Gang YU,Qiming CAO,Bin WANG,François VINCE,Youwei HONG

Frontiers of Environmental Science & Engineering 2015, Volume 9, Issue 3,   Pages 394-401 doi: 10.1007/s11783-014-0653-1

Abstract: The screening principle and the risk assessment were based on risk quotient ( ), which derived from the

Keywords： pharmaceuticals     aquatic environment     risk assessment     aquatic toxicity     risk quotient    

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Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Frontiers of Medicine 2016, Volume 10, Issue 2,   Pages 228-232 doi: 10.1007/s11684-016-0447-x

Abstract: New screening modalities using low-dose computerized tomography are promising tools for early detectionHowever, the screening and follow-up diagnostic procedures of these techniques may be costly.Focusing on prevention is an important factor to reduce the burden of screening, treatment, and lungthe societal burden of lung cancer, healthcare resources need to be focused on early detection and screening

Keywords： lung cancer     screening     risk factors     environmental    

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Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Frontiers of Chemical Science and Engineering 2022, Volume 16, Issue 1,   Pages 128-135 doi: 10.1007/s11705-021-2080-8

Abstract: The development of fluorophores emitting in the near-infrared spectral window has gained increased attention given their suitable features for biological imaging. In this work, we have optimised a general and straightforward synthetic approach to prepare a small library of near-infrared-emitting C-bridged nitrobenzodiazoles using commercial precursors. C-bridged benzodiazoles have low molecular weight and neutral character as important features that are not common in most near-infrared dyes. We have investigated their fluorescence response in the presence of a wide array of 60 different biomolecules and identified compound 3i as a potential chemosensor to discriminate between Fe2+ and Fe3+ ions in aqueous media.

Keywords： fluorescence     probes     iron     screening     library    

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Current situation and development of prenatal diagnosis in China

Xu-Ming BIAN, Qi GUO, Qing-Wei QI

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 271-274 doi: 10.1007/s11684-010-0100-z

Abstract: Prenatal screening and diagnosis are major methods for control of birth defects, which is a very importantHere, we review current situation and development of prenatal screening and diagnosis in mainland China, including prenatal screening and prenatal diagnosis of fetal chromosome abnormalities, non-invasive

Keywords： prenatal diagnosis     prenatal screening     China    

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Machine Learning-Assisted High-Throughput Virtual Screening for On-Demand Customization of Advanced Energetic Article

Siwei Song, Yi Wang, Fang Chen, Mi Yan, Qinghua Zhang

Engineering 2022, Volume 10, Issue 3,   Pages 99-109 doi: 10.1016/j.eng.2022.01.008

Abstract: A high-throughput virtual screening (HTVS) system integrating on-demand molecular generation and machine

Keywords： Energetic materials     Machine learning     High-throughput virtual screening     Molecular properties     Synthesis    

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Title Author Date Type Operation

An integrated model for structure optimization and technology screening of urban wastewater systems

Yue HUANG,Xin DONG,Siyu ZENG,Jining CHEN

Journal Article

Low-dose CT for lung cancer screening: opportunities and challenges

Hongbing Shen

Journal Article

Systematic screening procedure and innovative energy-saving design for ionic liquid-based extractive

Journal Article

Screening of indicator pharmaceuticals and personal care products in landfill leachates: a case study

Journal Article

A Screening Model for Probiotics Against Specific Metabolic Diseases Based on Caco-2 Monolayer Membrane

Yang Liu, Jiang Peng, Shiya Zhu, Leilei Yu, Fengwei Tian, Jianxin Zhao, Hao Zhang, Wei Chen, Qixiao Zhai

Journal Article

Combination of ARTP mutagenesis and color-mediated high-throughput screening to enhance 1-naphthol yield

Chenggang Qiu, Alei Zhang, Sha Tao, Kang Li, Kequan Chen, Pingkai Ouyang

Journal Article

Status of hyperhomocysteinemia in China: results from the China Stroke High-risk Population Screening

Journal Article

Screening of potential aquatic probiotics from the major microflora of guppies (

Aparna BALAKRISHNA, T. R. KEERTHI

Journal Article

Low-k integration: Gas screening for cryogenic etching and plasma damage mitigation

Romain Chanson, Remi Dussart, Thomas Tillocher, P. Lefaucheux, Christian Dussarrat, Jean François de Marneffe

Journal Article

High-Throughput Screening Using Fourier-Transform Infrared Imaging

Erdem Sasmaz, Kathleen Mingle, Jochen Lauterbach

Journal Article

Pharmaceutical compounds in aquatic environment in China: locally screening and environmental risk assessment

Yongshan CHEN,Xiuping XI,Gang YU,Qiming CAO,Bin WANG,François VINCE,Youwei HONG

Journal Article

Curbing the burden of lung cancer

Alexandra Urman,H. Dean Hosgood

Journal Article

Near-infrared benzodiazoles as small molecule environmentally-sensitive fluorophores

Journal Article

Current situation and development of prenatal diagnosis in China

Xu-Ming BIAN, Qi GUO, Qing-Wei QI

Journal Article

Machine Learning-Assisted High-Throughput Virtual Screening for On-Demand Customization of Advanced Energetic

Siwei Song, Yi Wang, Fang Chen, Mi Yan, Qinghua Zhang

Journal Article